Focus Areas of Research

  • Brain MRI with structural assessment of brain volumes, cortical thickness and fiber tracts.
  • Brain MRI with functional assessment of resting state activity, stimulation evoked activation and brain metabolites.
  • Explorative studies of brain function and neuroplastic reorganisation in chronic pain and neuropathic disorders, including evaluation of intervention and pharmacological treatment.
  • Pancreatic MRI with advanced assessment of structural and functional changes in pancreatic diseases, including exploration of the pathophysiology involved in chronic pancreatitis.
  • Gastrointestinal motility MRI with assessment of small bowel motility and colonic volume, including exploration of motility in diseases and interventional studies.

Responsible Researcher

Professor Jens Brøndum Frøkjær, MD, PhD

Selected Publications

  1. Frøkjær JB, Olesen SS, Gram M, Yavarian Y, Bouwense SAW, Wilder-Smith OHG, Drewes AM. Altered Brain Microstructure assessed by Diffusion Tensor Imaging in Patients with Chronic Pancreatitis. Gut. 2011 Nov;60(11):1554-62. Editorial in Gut. 2011 Nov;60(11):1445-6.
  2. Frøkjær JB, Bouwense SAW, Olesen SS, Lundager FH, Eskildsen SF, van Goor H, Wilder-Smith OHG, Drewes AM. Reduced cortical thickness of brain areas involved in pain processing in patients with chronic pancreatitis. Clin Gastroenterol Hepatol. 2012 Apr;10(4):434-438.
  3. JB Frøkjær, LW Andersen, C Brock, M Simrén, M Ljungberg, E Søfteland, G Dimcevski, Y Yavarian, H Gregersen, AM Drewes. Altered Brain Microstructure Assessed by Diffusion Tensor Imaging in Patients with Diabetes Mellitus and Gastrointestinal Symptoms. Diabetes Care. 2013 Mar;36(3):662-8.
  4. Frøkjær JB, Brock C, Søfteland E, Dimcevski G, Gregersen H, Simrén M, Drewes AM. Macrostructural brain changes in patients with longstanding type 1 diabetes mellitus - a cortical thickness analysis study. Exp Clin Endocrinol Diabetes. 2013 Jun;121(6):354-60.
  5.  Hansen TM, Olesen AE, Graversen C, Drewes AM, Frøkjaer JB. The Effect of Oral Morphine on Pain-Related Brain Activation - An Experimental Functional Magnetic Resonance Imaging Study. Basic Clin Pharmacol Toxicol. 2015 Nov;117(5):316-22.
  6. Hansen TM, Olesen AE, Simonsen CW, Fischer IW, Lelic D, Drewes AM, Frøkjaer JB. Acute Metabolic Changes Associated With Analgesic Drugs: An MR Spectroscopy Study. J Neuroimaging. 2016 Sep;26(5):545-51.